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The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo

It engages binding sites with approximately ten times greater affinity than that of comparable NNMT inhibitors [2]

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While theres no direct evidence suggesting harm in using Semaglutide and AOD 9604 together, theres limited research on their combined efficacy